NOVA Health Recovery Ketamine Infusion Center offers Ketamine infusions for Depression, Anxiety, PTSD, Chronic pain. We use intravenous and oral ketamine along with ketamine assisted psychotherapy (KAP) to treat multiple mood disorders. Northern Virginia Ketamine | Contact us below by email and leave your phone number as well, or call 703-844-0184 for an immediate appointment.
Ketamine for PTSD and co-occurring depression
A study linked above demonstrated the effective use of 6 ketamine infusions in veterans with comorbid PTSD and treatment resistant depression.
Total number of patients: 15
Six Ketamine infusions received Monday, Wednesday, Friday over two weeks at doses of 0.5 mg/kg over 40 minutes.
Data using the PTSD score and Montgomery-Asberg Depression Rating Scale score of depression which was collected before treatment, 24 hours later, and then weekly for 8 weeks.
Results: The remission rate for PTSD was 80.0%, and the response rate for TRD was 93.3%. Participants in remission from PTSD after the infusion series (n = 12) had a median time to relapse of 41 days. Similarly, participants whose depression symptoms responded to the infusion series (n = 14) had a median time to relapse of 20 days.
Generally, antidepressants such as SSRIs are used to treat PTSD and TRD (treatment resistant depression) and only 36.8% of patients with MDD remit with the first antidepressant used per STAR*D trial data. Treatment of PTSD with SSRIs leaves abundant residual symptoms as well. Ketamine does not worsen acute stress in PTSD patients.
Multiple trials have demonstrated efficacy of ketamine in MDD (Major Depressive Disorder):
The trajectory of treatment in the above single dose ketamine studies demonstrated a positive response at 24 hours that declined over 7-14 days.
Although comorbid PTSD and MDD occur together, there are few effective treatments for either. The trial referenced in this article attempts to intervene on patients who have FAILED two antidepressant medications.
One study in ketamine therapy of chronic PTSD demonstrated a rapid and significant reduction in symptoms.
Other studies have demonstrated that repeat ketamine infusions have prolonged improvements of mood in MDD and TRD.
Serial Ketamine studies with links are below:
Other trials of ketamine in PTSD:
- Feder et al: Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress DisorderA Randomized Clinical Trial This was the first randomized trial of ketamine for PTSD. The findings demonstrated a greater reduction of PTSD symptoms following treatment with ketamine was evident in both crossover and first-period analyses, and remained significant after adjusting for baseline and 24-hour depressive symptom severity. Ketamine was also associated with reduction in comorbid depressive symptoms and with improvement in overall clinical presentation. There was a single ketamine infusion of 0.5 mg/kg infused over 40 minutes. The effects lasted up to 7 days.
- Efficacy, Safety, and Durability of Repeated Ketamine Infusions for Comorbid Posttraumatic Stress Disorder and Treatment-Resistant Depression The remission rate for PTSD was 80.0%, and the response rate for TRD was 93.3%. Participants in remission from PTSD after the infusion series (n = 12) had a median time to relapse of 41 days. Similarly, participants whose depression symptoms responded to the infusion series (n = 14) had a median time to relapse of 20 days. Repeated ketamine infusions were associated with transient increases in dissociative symptoms. No participant reported worsening of PTSD symptoms over the study duration.
- Impact of oral ketamine augmentation on hospital admissions in treatment-resistant depression and PTSD: a retrospective study Oral doses of 0.5 mg/kg up to 7 mg/kg were used in a retrospective study and demonstrated inpatient hospital days were reduced by 70%, and hospital admissions were reduced by 65%.
- The correlation between ketamine and posttraumatic stress disorder in burned service members Perioperative soldiers who received ketamine had a 27% incidence of PTSD versus 49% of those who did not.
A further recent review of ketamine for PTSD is linked HERE and HERE
Ketamine with exposure-based therapy also represents an option to augment its treatment effects. Trials are ongoing regarding this option.
What are the standard therapies for PTSD?
- Psychotherapy
- EMDR
- Exposure-based therapies
- FDA Approved SSRI’s for PTSD
- Atypical antipsychotics such as quetiapine and risperidone.
- Prazosin for nightmares and insomnia
- Benzodiazepines such as valium
Ketamine therapy appears to be an effective adjunct treatment for PTSD.
NOVA Health Recovery is a Ketamine Treatment Center in Fairfax, Virginia (Northern Virginia Ketamine) that specializes in the treatment of depression, anxiety, bipolar disorder, OCD, and chronic pain such as CRPS, cluster headaches, and fibromyalgia using Ketamine therapies, both infusion and home-based ketamine nasal spray and oral tablets. We also offer addiction treatment services with Suboxone, Vivitrol, and Sublocade therapies for opiate addiction as well as alcohol treatment regimens. Contact us at 703-844-0184 or at this link: NOVA Health Recovery Ketamine Infusion Center Near me Ketamine Infusion
Ketamine Provider | Ketamine near me | Psychedelic assisted therapy | Mushrooms | Ketamine assisted psychotherapy | Ketamine psychedelic therapy | KAP | K hole | New depression Treatments | Areas we serve:
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